Neurofilament Light (NF-L) Rabbit Polyclonal Antibody

Cat Number: AB-84805
Conjugate: Unconjugated
Size: 100 ug
Clone: POLY
Concentration: 1mg/ml
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from the C-terminal region of human NF-L.
Reactivity: Human,Mouse,Rat

Western Blot: 1/500 – 1/2000
Immunohistochemistry (paraffin embedded tissues): 1:100-300

Molecular Weight: 61kD
Purification: Store at -20°C. Avoid repeated freeze-thaw cycles.
Synonyms: NEFL; NF68; NFL; Neurofilament light polypeptide; NF-L; 68 kDa neurofilament protein; Neurofilament triplet L protein.

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.

Form: Liquid
Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20°C. Avoid repeated freeze-thaw cycles.

Western Blot analysis of extracts from Jurkat cells, using NF-L Polyclonal Antibody. Secondary antibody was diluted at 1:20000


Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100.