Phospho-Caspase-3 (S150)
| Cat Number: | ABP10164 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100 ug |
| Clone: | Poly |
| Concentration: | 1mg/ml |
| Host: | Rb |
| Isotype: | IgG |
| Immunogen: | Synthesized peptide derived from human Caspase-3 around the phosphorylation site of S150. |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western Blot: 1:500-1:2000 |
| Molecular Weight: | 34 kDA |
| Purification: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Synonyms: | Caspase-3 CASP-3 Apopain Cysteine protease CPP32 CPP-32 Protein Yama SREBP cleavage activity 1 SCA-1 Caspase-3 subunit p17 Caspase-3 subunit P12 |
| Background: | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADPribose) polymerase (PARP) at a ‘216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. |
| Form: | liquid |
| Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage: | Store at -20°C, and avoid repeat freeze-thaw cycles. |
Western Blot (WB) analysis of HBE using p-Caspase-3 (S150) antibody