Phospho-HDAC4 (S632)
| Cat Number: | ABP-0359 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100 ug |
| Clone: | Poly |
| Concentration: | 1mg/ml |
| Host: | Rb |
| Isotype: | IgG |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S632 of human HDAC4 |
| Reactivity: | Hu, Ms, Rt |
| Applications: | WB 1:500-1:2000 |
| Molecular Weight: | 140kDa |
| Purification: | Affinity purification |
| Background: | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. |
| Form: | liquid |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20oC or -80oC. Avoid freeze / thaw cycles. |
Western blot analysis of extracts from 293 cells using Phospho-HDAC4-S632 antibody