Phospho-HDAC6 (Ser22) Rabbit Polyclonal Antibody
| Cat Number: | ABN00938 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100ul |
| Clone: | POLY |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | A synthetic Phosphorylated peptide corresponding to residues target protein |
| Reactivity: | Human,Mouse |
| Applications: | WB 1:500-1:1000 |
| Molecular: | 131 kDa |
| Purification: | Affinity purification |
| Synonyms: | HDAC6; KIAA0901; JM21; Histone deacetylase 6; HD6 |
| Background: | Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases. |
| Form: | liquid |
| Buffer: | Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% sodium azide, pH 7.3. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Western blot analysis of Phospho-HDAC6 (Ser22) in 3T3 lysates using Phospho-HDAC6 (Ser22) antibody.