Phospho-JAK2 (Tyr1007) Rabbit Polyclonal Antibody
| Cat Number: | ABP-0373 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 200μL |
| Clone: | POLY |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Reactivity: | Human,Mouse,Rat |
| Applications: | WB 1:500-1:1000,IHC 1:50-1:100,ELISA 1:5000-1:20000 |
| Molecular: | 131 kDa |
| Purification: | Affinity purification |
| Synonyms: | JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2 |
| Background: | Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. |
| Form: | liquid |
| Buffer: | Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% sodium azide, pH 7.3. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Western blot analysis of Phospho-JAK2 (Tyr1007) in NIH3T3 lysates using Phospho-JAK2 (Tyr1007) antibody.