Phospho-Rb (Ser780) Rabbit Monoclonal Antibody
| Cat Number: | MABN84879 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Monoclonal |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | A synthetic phosphopeptide corresponding to residues surrounding Ser780 of human Rb |
| Reactivity: | Human,Rat |
| Applications: | WB 1:500-1:1000,IP 1:10-1:20 |
| Molecular: | Calculated MW: 106 kDa; Observed MW: 110 kDa |
| Purification: | Affinity Purification |
| Synonyms: | RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110 |
| Background: | Cell cycle-dependent phosphorylation by a CDK inhibits Rb target binding and allows cell cycle progression. Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4/6 followed by cyclin E-CDK2 phosphorylation. Specificity of different CDK/cyclin complexes has been observed in vitro and cyclin D1 is required for Ser780 phosphorylation in vivo. |
| Form: | Liquid |
| Buffer: | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |