Phospho-Synuclein-α (S129)

Cat Number: ABP-0450
Conjugate: Unconjugated
Size: 100 ug
Clone: Poly
Concentration: 1mg/ml
Host: Rb
Isotype: IgG
Immunogen: Western blot analysis of extracts from Hela cells, using Phospho-NFKB-p65 (Thr435) antibody.
Reactivity: Hu, Ms, Rt

Western Blot: 1:1000

Molecular Weight: 18kDa
Purification: Affinity purification

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer’s disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Form: liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20°C. Avoid freeze / thaw cycles.

Western blot analysis of extracts of mouse brain tissue using Phospho-Synuclein Alpha Ser-129 antibody.