Phospho-Synuclein-α (S129)
| Cat Number: | ABP-0450 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100 ug |
| Clone: | Poly |
| Concentration: | 1mg/ml |
| Host: | Rb |
| Isotype: | IgG |
| Immunogen: | Western blot analysis of extracts from Hela cells, using Phospho-NFKB-p65 (Thr435) antibody. |
| Reactivity: | Hu, Ms, Rt |
| Applications: | Western Blot: 1:1000 |
| Molecular Weight: | 18kDa |
| Purification: | Affinity purification |
| Background: | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer’s disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. |
| Form: | liquid |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
Western blot analysis of extracts of mouse brain tissue using Phospho-Synuclein Alpha Ser-129 antibody.