STK11 Mouse Monoclonal Antibody
| Cat Number: | MABN80925 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Monoclonal |
| Concentration: | 1mg/ml |
| Host: | Mouse |
| Isotype: | Mouse IgG1 |
| Immunogen: | Purified recombinant fragment of human STK11 expressed in E. Coli. |
| Reactivity: | Human,Mouse,Monkey |
| Applications: | WB 1:500-1:2000,ELISA 1:5000-1:20000,FC 1:200-1:400 |
| Molecular: | 54kDa |
| Purification: | Affinity Purification |
| Synonyms: | PJS; LKB1; STK11 |
| Background: | Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.serine/threonine kinase 11,with two alternatively spliced isoforms,expressed in all tissues,strongly homolog of Xenopus early embryonic kinase 1 (XEEK1),tumor suppressor gene in hamartomas syndrome and in left sided colon carcinogenesis,mutated in sporadic testicular cancer,malignant melanomas and laryngeal tumors,playing a minor role in the development of ovarian carcinoma.LKB1 is a potential target for atherosclerosis and cancer and is shown to be mutated in patients with Peutz-Jeghers cancer syndrome. Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver. |
| Form: | Liquid |
| Buffer: | Ascitic fluid containing 0.03% sodium azide. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |