TPH1 (16G2) Rabbit Monoclonal Antibody
| Cat Number: | MABN19152 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Monoclonal |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | A synthetic peptide of human Tryptophan Hydroxylase |
| Reactivity: | Human,Mouse |
| Applications: | WB 1:500-1:2000,IHC 1:200-1:2000 |
| Molecular: | 51kDa |
| Purification: | Affinity purification |
| Synonyms: | TPH1;MGC119994;TPRH;TRPH;Tryptophan 5-hydroxylase 1; Tryptophan Hydroxylase; |
| Background: | Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin by converting tryptophan to 5-hydroxy-L-tryptophan. Two isoforms of TPH exist: TPH-1 is mainly expressed in the periphery, whereas the expression of TPH-2 is restricted to neuronal cells and the central nervous system. Most of the serotonin found throughout the body is synthesized by TPH-1 in enterochromaffin cells of the gastrointestinal tract. Targeted disruption of the tph1 gene results in low levels of circulating and tissue serotonin. Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate- determining step of serotonin biosynthesis. |
| Form: | Liquid |
| Buffer: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |