ZAP70 Mouse Monoclonal Antibody
| Cat Number: | MABN80539 |
|---|---|
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Clone: | Monoclonal |
| Concentration: | 1mg/ml |
| Host: | Mouse |
| Isotype: | Mouse IgG1 |
| Immunogen: | Purified recombinant fragment of human ZAP70 expressed in E. Coli. |
| Reactivity: | Human |
| Applications: | WB 1:500-1:2000,IHC 1:200-1:1000,ELISA 1:5000-1:20000 |
| Molecular: | 70kDa |
| Purification: | Affinity Purification |
| Synonyms: | SRK; STD; TZK |
| Background: | ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. ZAP70 controls TCR(T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene. ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia. |
| Form: | Liquid |
| Buffer: | Purified antibody in PBS with 0.05% sodium azide. |
| Storage: | Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles. |