5 Lipoxygenase Rabbit Monoclonal Antibody

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Catalog Number:MABN86792
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human 5 Lipoxygenase
Reactivity:Human,Rat
Applications:WB 1:500-1:2000,IHC 1:50-1:200,ICC/IF 1:100-1:200,FC 1:50-1:200
Molecular Weight:Calculated MW:78 kDa; Observed MW:78 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:5-LO; 5LPG; LOG5; 5-LOX

Applications

WB 1:500-1:2000,IHC 1:50-1:200,ICC/IF 1:100-1:200,FC 1:50-1:200

Immunogen

A synthetic peptide of human 5 Lipoxygenase

Target Background

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Synonyms:5-LO; 5LPG; LOG5; 5-LOX

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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