Immunological Sciences

53BP1 Rabbit Monoclonal Antibody

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Catalog Number:MABN87074
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human 53BP1
Reactivity:Human
Applications:WB 1:5000-1:50000,IHC 1:50-1:100,ICC/IF 1:100-1:200
Molecular Weight:Calculated MW:214 kDa; Observed MW:450 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:TP53; p202; 53BP1; TDRD30; p53BP1

Applications

WB 1:5000-1:50000,IHC 1:50-1:100,ICC/IF 1:100-1:200

Immunogen

A synthetic peptide of human 53BP1

Target Background

This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

Synonyms:TP53; p202; 53BP1; TDRD30; p53BP1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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