Immunological Sciences

Acetyl-Coenzyme A Carboxylase Rabbit Monoclonal Antibody

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Catalog Number:MABN86998
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Acetyl Coenzyme A Carboxylase
Reactivity:Human
Applications:WB 1:1000-1:5000,IHC 1:200-1:500,ICC/IF 1:100-1:200,FC 1:100-1:500
Molecular Weight:Calculated MW:277 kDa; Observed MW:277 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:ACC; ACAC; ACC1; ACCA; ACACAD

Applications

WB 1:1000-1:5000,IHC 1:200-1:500,ICC/IF 1:100-1:200,FC 1:100-1:500

Immunogen

A synthetic peptide of human Acetyl Coenzyme A Carboxylase

Target Background

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Synonyms:ACC; ACAC; ACC1; ACCA; ACACAD

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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