ADAM10 Rabbit Polyclonal Antibody

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Catalog Number:ABN00350
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:A synthetic peptide of human ADAM10
Reactivity:Human
Applications:WB 1:500-1:1000,IP 1:20-1:50
Molecular Weight:Calculated MW: 84 kDa; Observed MW: 90,68 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:CDw156; CD156c; ADAM10; KUZ; MADM

Applications

WB 1:500-1:1000,IP 1:20-1:50

Immunogen

A synthetic peptide of human ADAM10

Target Background

The ADAM10 prodomain acts as a chaperone that stabilizes mature ADAM protein folding, and prevents target-protein shedding through inhibition of ADAM10 proteinase activity. Mature ADAM10 is the major α-secretase responsible for cleavage of Notch, APP, cadherins, and prion protein. The ADAM10 protein cleaves receptor tyrosine kinases and their associated ligands and displays a wide range of regulatory functions across related signaling pathways.

Synonyms:CDw156; CD156c; ADAM10; KUZ; MADM

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

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