Immunological Sciences

AHA1 (3L10) Rabbit Monoclonal Antibody

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Catalog Number:MABN06690
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human AHA1
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000,IP 1:20-1:50
Molecular Weight:38kDa
Purification:Affinity purification
Form:Liquid
Synonyms:AHA 1; AHA1; AHSA 1; Ahsa1; C14orf3; HSPC322; p38;

Applications

WB 1:1000-1:5000,IP 1:20-1:50

Immunogen

A synthetic peptide of human AHA1

Target Background

Cochaperone that stimulates HSP90 ATPase activity (By similarity). May affect a step in the endoplasmic reticulum to Golgi trafficking. Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co- chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155).

Synonyms:AHA 1; AHA1; AHSA 1; Ahsa1; C14orf3; HSPC322; p38;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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