Immunological Sciences

AHA1 Rabbit Monoclonal Antibody

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Catalog Number:MABN86459
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human AHA1
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000,IP 1:20-1:50
Molecular Weight:Calculated MW:38 kDa; Observed MW:42 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:p38; AHA1; hAha1; C14orf3

Applications

WB 1:1000-1:5000,IP 1:20-1:50

Immunogen

A synthetic peptide of human AHA1

Target Background

Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155).

Synonyms:p38; AHA1; hAha1; C14orf3

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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