Immunological Sciences

ALAD Rabbit Monoclonal Antibody

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Catalog Number:MABN87491
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human ALAD
Reactivity:Human
Applications:WB 1:1000-1:5000,IHC 1:50-1:500
Molecular Weight:Calculated MW:36 kDa; Observed MW:36 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:PBGS; ALADH

Applications

WB 1:1000-1:5000,IHC 1:50-1:500

Immunogen

A synthetic peptide of human ALAD

Target Background

The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Synonyms:PBGS; ALADH

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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