Anti-Phospho- NF-kB p65 (S536) Rabbit pAb
Western blot analysis of phospho-p65 at dilution of 1: 600 Lane1: HeLa untreated Lane2: HeLa treated with 20ng/mL TNFα for 20min, whole cell lysate Lane3: MCF7 untreated Lane4: MCF7 treated with 20ng/ml TNFα for 20min, whole cell lysate
| Catalog Number: | ABS113882 |
| Conjugate: | unconjugated |
| Size: | 100 μL |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | KLH conjugated Synthetic phosphopeptide corresponding to Human NF-kB p65 (S536) |
| Reactivity: | Human, Mouse, Rat |
| Applications: | WB 1: 300-1: 600 |
| Molecular Weight: | 70 kDa |
| Purification: | Affinity purification |
| Form: | Liquid |
Nuclear factor k B (NF-kB) is a sequence-specific DNA-binding protein complex which regulates the expression of viral genomes, including the human immunodeficiency virus, and a variety of cellular genes, particularly those involved in immune and inflammatory responses. The members of the NF-kB family in mammalian cells include the proto-oncogene c-Rel,p50/p105 (NFkB1), p65 (RelA), p52/p100 (NFkB2), and RelB. All of these proteins share a conserved 300-amino acid region known as the Rel homology domain which is responsible for DNA binding, dimerization, and nuclear translocation of NF-kB. The p65 subunit is a major component of NF-kB complexes and is responsible for trans-activation. NF-kB heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators.
Applications
WB 1: 300-1: 600
Immunogen
KLH conjugated Synthetic phosphopeptide corresponding to Human NF-kB p65 (S536)
