APC Rabbit Monoclonal antibody
Immunocytochemistry analysis of APC (green) in LNcap using APC antibody, and DAPI (blue).
| Catalog Number: | MABN02900 |
| Conjugate: | Unconjugated |
| Size: | 100μL |
| Concentration: | 1mg/ml |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | A synthetic peptide of human APC |
| Reactivity: | Human |
| Applications: | WB 1:500-1:1000,ICC/IF 1:50-1:200,IP 1:20-1:50 |
| Molecular Weight: | 160 kDa |
| Purification: | Affinity purification |
| Form: | liquid |
| Synonyms: | APC; DP2.5; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5 |
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
Applications
WB 1:500-1:1000,ICC/IF 1:50-1:200,IP 1:20-1:50
Immunogen
A synthetic peptide of human APC
