APP Mouse Monoclonal Antibody
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
| Catalog Number: | MABN81357 |
| Conjugate: | Unconjugated |
| Size: | 100ul |
| Concentration: | 1mg/ml |
| Host: | Mouse |
| Isotype: | Mouse IgG1 |
| Clone: | Monoclonal |
| Immunogen: | Purified recombinant fragment of human APP (AA: 483-699) expressed in E. Coli. |
| Reactivity: | Human |
| Applications: | ICC 1:200-1:1000,ELISA 1:5000-1:20000 |
| Molecular Weight: | 87kDa |
| Purification: | Affinity purification |
| Form: | liquid |
| Synonyms: | AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma |
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Applications
ICC 1:200-1:1000,ELISA 1:5000-1:20000
Immunogen
Purified recombinant fragment of human APP (AA: 483-699) expressed in E. Coli.
