Argonaute 2 Rabbit Monoclonal Antibody

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Catalog Number:MABN01673
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Argonaute-2
Reactivity:Human,Rat
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 97 kDa; Observed MW: 97 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Ago 2; Argonaute 2; dAgo2; eIF2C 2; hAgo2; PPD

Applications

WB 1:500-1:1000

Immunogen

A synthetic peptide of human Argonaute-2

Target Background

Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). Can also upregulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and upregulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.

Synonyms:Ago 2; Argonaute 2; dAgo2; eIF2C 2; hAgo2; PPD

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

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