Immunological Sciences

ATM (9F7) Mouse Monoclonal Antibody

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Catalog Number:MABN00765
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:IgG1
Clone:Monoclonal
Immunogen:A synthetic peptide corresponding to target protein
Reactivity:Human,Rat,Mouse
Applications:IHC 1:50-1:100
Purification:Affinity Purification
Form:Liquid
Synonyms:ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated

Applications

IHC 1:50-1:100

Immunogen

A synthetic peptide corresponding to target protein

Target Background

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.

Synonyms:ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

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