Immunological Sciences

ATM Mouse Monoclonal Antibody

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Catalog Number:MABN82985
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG2a
Clone:Monoclonal
Immunogen:Purified recombinant fragment of human ATM (AA: 2577-3056) expressed in E. Coli.
Reactivity:Other
Applications:IHC 1:200-1:1000,ELISA 1:5000-1:20000,FC 1:200-1:400
Molecular Weight:350.7kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1

Applications

IHC 1:200-1:1000,ELISA 1:5000-1:20000,FC 1:200-1:400

Immunogen

Purified recombinant fragment of human ATM (AA: 2577-3056) expressed in E. Coli.

Target Background

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Synonyms:AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide

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