Immunological Sciences

ATM Rabbit Monoclonal Antibody

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Catalog Number:MABN01480
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide corresponding to target protein
Reactivity:Human
Applications:WB 1:500-1:1000,ICC/IF 1:50-1:200
Molecular Weight:Calculated MW: 351 kDa; Observed MW: 351 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated

Applications

WB 1:500-1:1000,ICC/IF 1:50-1:200

Immunogen

A synthetic peptide corresponding to target protein

Target Background

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.

Synonyms:ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

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