ATR Mouse Monoclonal Antibody

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Catalog Number:MABN82304
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:Purified recombinant fragment of human ATR (AA: 366-550) expressed in E. Coli.
Reactivity:Human
Applications:ELISA 1:5000-1:20000,FC 1:200-1:400
Molecular Weight:301kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:FRP1; MEC1; SCKL; FCTCS; SCKL1

Applications

ELISA 1:5000-1:20000,FC 1:200-1:400

Immunogen

Purified recombinant fragment of human ATR (AA: 366-550) expressed in E. Coli.

Target Background

The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.

Synonyms:FRP1; MEC1; SCKL; FCTCS; SCKL1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide

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