B7H3 Mouse Monoclonal Antibody

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Catalog Number:MABN81994
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:Purified recombinant fragment of human B7H3 (AA: extra 29-466) expressed in HEK293 cells.
Reactivity:Human
Applications:IHC 1:200-1:1000,ICC 1:100-1:500,ELISA 1:5000-1:20000,FC 1:200-1:400
Molecular Weight:57.2kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:CD276; B7-H3; B7RP-2; 4Ig-B7-H3

Applications

IHC 1:200-1:1000,ICC 1:100-1:500,ELISA 1:5000-1:20000,FC 1:200-1:400

Immunogen

Purified recombinant fragment of human B7H3 (AA: extra 29-466) expressed in HEK293 cells.

Target Background

The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms:CD276; B7-H3; B7RP-2; 4Ig-B7-H3

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide

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