Immunological Sciences

Bag3 Rabbit Monoclonal Antibody

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Catalog Number:MABN86693
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Bag3
Reactivity:Human,Mouse
Applications:WB 1:1000-1:5000,IP 1:10-1:100
Molecular Weight:Calculated MW:62 kDa; Observed MW:74-80 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:BIS; MFM6; BAG-3; CAIR-1

Applications

WB 1:1000-1:5000,IP 1:10-1:100

Immunogen

A synthetic peptide of human Bag3

Target Background

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

Synonyms:BIS; MFM6; BAG-3; CAIR-1

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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