Immunological Sciences

BAP1 Rabbit Monoclonal Antibody

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Catalog Number:MABN87019
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human BAP1
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:50-1:200,FC 1:50-1:100
Molecular Weight:Calculated MW:80 kDa; Observed MW:95 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:UCHL2; hucep-6; HUCEP-13

Applications

WB 1:500-1:2000,IHC 1:50-1:200,FC 1:50-1:100

Immunogen

Recombinant protein of human BAP1

Target Background

This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]

Synonyms:UCHL2; hucep-6; HUCEP-13

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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