Immunological Sciences

Bax (2B12) Mouse Monoclonal Antibody

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Catalog Number:MABN03509
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:IgG2a
Clone:Monoclonal
Immunogen:A synthetic peptide of human Bax
Reactivity:Human,Monkey
Applications:WB 1:500-1:1000
Molecular Weight:Calculated MW: 21 kDa; Observed MW: 21 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Apoptosis regulator BAX; BAX; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4

Applications

WB 1:500-1:1000

Immunogen

A synthetic peptide of human Bax

Target Background

Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis.

Synonyms:Apoptosis regulator BAX; BAX; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

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