Immunological Sciences

BAX Mouse Monoclonal Antibody

No images available

Catalog Number:MABN81892
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG2a
Clone:Monoclonal
Immunogen:Purified recombinant fragment of human BAX (AA: 13-160) expressed in E. Coli.
Reactivity:Human,Mouse,Rat,Rabbit,Monkey
Applications:WB 1:500-1:1000,IHC 1:200-1:1000,ELISA 1:5000-1:20000,FC 1:200-1:400
Molecular Weight:21.2kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:BCL2L4

Applications

WB 1:500-1:1000,IHC 1:200-1:1000,ELISA 1:5000-1:20000,FC 1:200-1:400

Immunogen

Purified recombinant fragment of human BAX (AA: 13-160) expressed in E. Coli.

Target Background

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Synonyms:BCL2L4

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide

No documents available.