Immunological Sciences

Bax Rabbit Monoclonal Antibody

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Catalog Number:MABN21477
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG,Kappa
Clone:Monoclonal
Immunogen:A synthetic peptide of human Bax
Reactivity:Human,Mouse,Rat,
Applications:WB 1:1000-1:5000,IHC 1:2000-1:5000,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200
Molecular Weight:CalcuLated MW:21kD;Observed MW:21kD
Purification:Protein A
Form:Liquid
Synonyms:BAX;BCL2L4;Apoptosis reguLator BAX;Bcl-2-like protein 4;Bcl2-L-4

Applications

WB 1:1000-1:5000,IHC 1:2000-1:5000,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200

Immunogen

A synthetic peptide of human Bax

Target Background

Cell localization:Cytoplasm, Nuclear.The protein encoded by BAX (BCL2 associated X, apoptosis regulator) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for BAX.

Synonyms:BAX;BCL2L4;Apoptosis reguLator BAX;Bcl-2-like protein 4;Bcl2-L-4

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

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