Immunological Sciences

BBS1 Rabbit Monoclonal Antibody

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Catalog Number:MABN03917
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human BBS1
Reactivity:Human, Mouse, Rat
Applications:WB 1:500-1:1000,ICC/IF 1:50-1:200
Molecular Weight:Calculated MW:65 kDa;Observed MW: 65 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:BBS1,BBS2L2,Bardet-Biedl syndrome 1 protein,BBS2-like protein 2

Applications

WB 1:500-1:1000,ICC/IF 1:50-1:200

Immunogen

A synthetic peptide of human BBS1

Target Background

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (PubMed:17574030, PubMed:22072986).Plays a role in olfactory cilium biogenesis/maintenance and trafficking (By similarity).

Synonyms:BBS1,BBS2L2,Bardet-Biedl syndrome 1 protein,BBS2-like protein 2

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

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