Immunological Sciences

BCL10 Mouse Monoclonal Antibody

No images available

Catalog Number:MABN82142
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:Purified recombinant fragment of human BCL10 (AA: 98-234) expressed in E. Coli.
Reactivity:Human
Applications:ELISA 1:5000-1:20000,FC 1:200-1:400
Molecular Weight:26.3kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:CLAP; mE10; CIPER; IMD37; c-E10; CARMEN

Applications

ELISA 1:5000-1:20000,FC 1:200-1:400

Immunogen

Purified recombinant fragment of human BCL10 (AA: 98-234) expressed in E. Coli.

Target Background

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.

Synonyms:CLAP; mE10; CIPER; IMD37; c-E10; CARMEN

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide

No documents available.