Immunological Sciences

Bcl10 Rabbit Monoclonal Antibody

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Catalog Number:MABN86954
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human Bcl10
Reactivity:Human
Applications:WB 1:1000-1:5000,IHC 1:50-1:100,ICC/IF 1:100-1:200,FC 1:100-1:200,IP 1:20-1:50
Molecular Weight:Calculated MW:26 kDa; Observed MW:26 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:CLAP; mE10; CIPER; IMD37; c-E10; CARMEN

Applications

WB 1:1000-1:5000,IHC 1:50-1:100,ICC/IF 1:100-1:200,FC 1:100-1:200,IP 1:20-1:50

Immunogen

A synthetic peptide of human Bcl10

Target Background

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Synonyms:CLAP; mE10; CIPER; IMD37; c-E10; CARMEN

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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