Immunological Sciences

BCR Rabbit Monoclonal Antibody

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Catalog Number:MABN87495
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human BCR
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:200-1:500,FC 1:200-1:500,IP 1:20-1:50
Molecular Weight:Calculated MW:143 kDa; Observed MW:150 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:ALL; CML; PHL; BCR1; D22S11; D22S662

Applications

WB 1:500-1:2000,IHC 1:200-1:500,FC 1:200-1:500,IP 1:20-1:50

Immunogen

Recombinant protein of human BCR

Target Background

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Synonyms:ALL; CML; PHL; BCR1; D22S11; D22S662

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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