Immunological Sciences

beta Catenin Rabbit Monoclonal Antibody

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Catalog Number:MABN86528
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human beta Catenin
Reactivity:Human, Mouse, Rat
Applications:WB 1:500-1:2000,IHC 1:500-1:2000,ICC/IF 1:20-1:50,FC 1:500-1:2000
Molecular Weight:Calculated MW:86 kDa; Observed MW:86 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:EVR7; CTNNB; MRD19; NEDSDV; armadillo

Applications

WB 1:500-1:2000,IHC 1:500-1:2000,ICC/IF 1:20-1:50,FC 1:500-1:2000

Immunogen

A synthetic peptide of human beta Catenin

Target Background

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Synonyms:EVR7; CTNNB; MRD19; NEDSDV; armadillo

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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