BIN1 (14G10) Rabbit Monoclonal Antibody

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Catalog Number:MABN07564
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human BIN1
Reactivity:Human
Applications:WB 1:1000-1:5000,IHC 1:100-1:500,ICC/IF 1:100-1:200,FC 1:20-1:50,IP 1:20-1:50
Molecular Weight:65kDa
Purification:Affinity purification
Form:Liquid
Synonyms:AMPH2; Amphiphysin 2; Amphiphysin II; AMPHL; Bin1; Bridging integrator 1; SH3P9;

Applications

WB 1:1000-1:5000,IHC 1:100-1:500,ICC/IF 1:100-1:200,FC 1:20-1:50,IP 1:20-1:50

Immunogen

Recombinant protein of human BIN1

Target Background

May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation. Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863).

Synonyms:AMPH2; Amphiphysin 2; Amphiphysin II; AMPHL; Bin1; Bridging integrator 1; SH3P9;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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