Immunological Sciences

BMAL1 Rabbit Monoclonal Antibody

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Catalog Number:MABN87713
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human BMAL1
Reactivity:Human, Mouse, Rat
Applications:WB 1:500-1:2000,IHC 1:200-1:1000,ICC/IF 1:100-1:200,IP 1:20-1:40
Molecular Weight:Calculated MW:69 kDa; Observed MW:78 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:TIC; JAP3; MOP3; ARNTL; PASD3; ARNTL1; BMAL1c; bHLHe5

Applications

WB 1:500-1:2000,IHC 1:200-1:1000,ICC/IF 1:100-1:200,IP 1:20-1:40

Immunogen

A synthetic peptide of human BMAL1

Target Background

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19. [provided by RefSeq, Oct 2021]

Synonyms:TIC; JAP3; MOP3; ARNTL; PASD3; ARNTL1; BMAL1c; bHLHe5

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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