Immunological Sciences

BOB1 (10L9) Rabbit Monoclonal Antibody

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Catalog Number:MABN07623
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human BOB1
Reactivity:Human
Applications:WB 1:1000-1:5000
Molecular Weight:27kDa
Purification:Affinity purification
Form:Liquid
Synonyms:BOB 1; BOB-1; OBF 1; OBF1; OCA B; OCA-B; OCAB; OCT binding factor 1; Pou2af1;

Applications

WB 1:1000-1:5000

Immunogen

A synthetic peptide of human BOB1

Target Background

Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 (PubMed:7859290). It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2 (PubMed:7779176). It has no intrinsic DNA-binding activity. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2 (PubMed:7779176). It is essential for the response of B-cells to antigens and required for the formation of germinal centers (PubMed:7623806, PubMed:7859290). Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (By similarity).

Synonyms:BOB 1; BOB-1; OBF 1; OBF1; OCA B; OCA-B; OCAB; OCT binding factor 1; Pou2af1;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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