Immunological Sciences

BRCC36 Rabbit Monoclonal Antibody

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Catalog Number:MABN86687
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human BRCC36
Reactivity:Human,Mouse,Rat
Applications:WB 1:1000-1:5000
Molecular Weight:Calculated MW:36 kDa; Observed MW:36 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:C6.1A; BRCC36; CXorf53

Applications

WB 1:1000-1:5000

Immunogen

A synthetic peptide of human BRCC36

Target Background

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]

Synonyms:C6.1A; BRCC36; CXorf53

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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