BrightRed 780 Anti-Human CD127/IL-7RA Antibody[A019D5]
Human peripheral blood lymphocytes are stained with FITC Anti-Human CD3 Antibody and BrightRed 780 Anti-Human CD127/IL-7RA Antibody (Left). Lymphocytes are stained with FITC Anti-Human CD3 Antibody and BrightRed 780 Mouse IgG1, κ Isotype Control (Right).
| Catalog Number: | MAB1152S |
| Conjugate: | BrightRed 780 |
| Size: | 100Tests |
| Concentration: | 5 μL/Test |
| Host: | Mouse |
| Isotype: | Mouse IgG1, κ |
| Clone: | Monoclonal |
| Reactivity: | Human |
| Applications: | Each lot of this antibody is quality control tested by flow cytometric analysis. <b style="color:#0070ca">The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood).</b> Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. |
| Form: | Liquid |
| Synonyms: | IL7R;CD127;CDW127;IL-7R-alpha;IL7RA;ILRA |
CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.
Applications
Each lot of this antibody is quality control tested by flow cytometric analysis. <b style="color:#0070ca">The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood).</b> Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.