BST-1 Rabbit Polyclonal Antibody

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Catalog Number:ABN07674
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Polyclonal
Immunogen:The antiserum was produced against synthesized peptide derived from human BST1. AA range:71-120
Reactivity:Human,Mouse,Rat,Monkey
Applications:WB 1:500-1:2000,ELISA 1:20000-1:40000
Molecular Weight:34kDa
Purification:Affinity purification
Form:Liquid
Synonyms:BST1; ADP-ribosyl cyclase 2; Bone marrow stromal antigen 1; BST-1; Cyclic ADP-ribose hydrolase 2; cADPr hydrolase 2; CD antigen CD157

Applications

WB 1:500-1:2000,ELISA 1:20000-1:40000

Immunogen

The antiserum was produced against synthesized peptide derived from human BST1. AA range:71-120

Target Background

Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008],catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,disease:Rheumatoid arthritis (RA) patients show enhanced expression of BST-1 transcripts in bone marrow stromal cell lines. This suggests that BST-1 overexpression may play a role in B-cell abnormalities in RA.,function:Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.,similarity:Belongs to the ADP-ribosyl cyclase family.,subunit:Homodimer.,tissue specificity:Widely expressed.,

Synonyms:BST1; ADP-ribosyl cyclase 2; Bone marrow stromal antigen 1; BST-1; Cyclic ADP-ribose hydrolase 2; cADPr hydrolase 2; CD antigen CD157

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

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