C-CBL Mouse Monoclonal Antibody

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Catalog Number:MABN81023
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Mouse
Isotype:Mouse IgG1
Clone:Monoclonal
Immunogen:Purified recombinant fragment of human C-CBL expressed in E. Coli.
Reactivity:Human,Mouse,Rat,Monkey,Rabbit
Applications:WB 1:500-1:2000,IHC 1:100-1:500,ICC 1:50-1:500,ELISA 1:5000-1:20000,FC 1:200-1:400
Molecular Weight:120kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:CBL; CBL2; NSLL; C-CBL; RNF55

Applications

WB 1:500-1:2000,IHC 1:100-1:500,ICC 1:50-1:500,ELISA 1:5000-1:20000,FC 1:200-1:400

Immunogen

Purified recombinant fragment of human C-CBL expressed in E. Coli.

Target Background

The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.

Synonyms:CBL; CBL2; NSLL; C-CBL; RNF55

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide.

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