Immunological Sciences

C14orf169/NO66 Rabbit Monoclonal Antibody

No images available

Catalog Number:MABN86570
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of human C14orf169/NO66
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IP 1:50-1:100
Molecular Weight:Calculated MW:71 kDa; Observed MW:71 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:ROX; NO66; JMJD9; MAPJD; URLC2; hsNO66; C14orf169

Applications

WB 1:500-1:2000,IP 1:50-1:100

Immunogen

Recombinant protein of human C14orf169/NO66

Target Background

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.

Synonyms:ROX; NO66; JMJD9; MAPJD; URLC2; hsNO66; C14orf169

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

No documents available.