Immunological Sciences

Caspase 11 Rabbit Monoclonal Antibody

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Catalog Number:MABN85381
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of mouse Caspase-11
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:1000,IP 1:10-1:20
Molecular Weight:Calculated MW: 43 kDa; Observed MW: 43,38,25 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:Caspl; ich-3; CASP-4; Casp11; CASP-11

Applications

WB 1:500-1:1000,IP 1:10-1:20

Immunogen

Recombinant protein of mouse Caspase-11

Target Background

Proinflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators.

Synonyms:Caspl; ich-3; CASP-4; Casp11; CASP-11

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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