Immunological Sciences

Catenin alpha-1/CTNNA1

NIH/3T3 cells were subjected to SDS PAGE followed by western blot with (CTNNA1 Antibody) at dilution of 1:1000

NIH/3T3 cells were subjected to SDS PAGE followed by western blot with (CTNNA1 Antibody) at dilution of 1:1000

Catalog Number:MAB-94590
Size:100 ug
Concentration:1mg/ml
Host:Ms
Isotype:IgG1
Clone:alpha-CAT-7A4
Immunogen:catenin(cadherin-associated protein), alpha 1, 102kDa
Reactivity:Hu, Ms
Applications:Western Blot: 1:500-1:2000 Immunohistochemistry (paraffin-embedded tissues):1:50-1:1000
Molecular Weight:95-100kDa
Purification:Protein A+G purification .
Form:Liquid
Synonyms:Alpha E catenin, Cadherin associated protein, CAP102, Catenin alpha 1, CTNNA1

Applications

Western Blot: 1:500-1:2000 Immunohistochemistry (paraffin-embedded tissues):1:50-1:1000

Immunogen

catenin(cadherin-associated protein), alpha 1, 102kDa

Target Background

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E-and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Synonyms:Alpha E catenin, Cadherin associated protein, CAP102, Catenin alpha 1, CTNNA1

Storage

Storage-20℃ for 12 months (Avoid repeated freeze / thaw cycles.) T483

Buffer

PBS with 0.02% sodium azide and 50% glycerol pH 7.3

NIH/3T3 cells were subjected to SDS PAGE followed by western blot with (CTNNA1 Antibody) at dilution of 1:1000

Immunohistochemistry of paraffin-embedded human stomach tissue slide using (CTNNA1 Antibody) at dilution of 1:200

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