CBX4 (10P4) Rabbit Monoclonal Antibody

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Catalog Number:MABN08056
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human CBX4
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:100-1:200,FC 1:200-1:500,IP 1:20-1:50,IF-P 1:100-1:200
Molecular Weight:61kDa
Purification:Affinity purification
Form:Liquid
Synonyms:CBX4; hPc2; NBP16; PC2;

Applications

WB 1:500-1:2000,IHC 1:100-1:200,FC 1:200-1:500,IP 1:20-1:50,IF-P 1:100-1:200

Immunogen

A synthetic peptide of human CBX4

Target Background

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850).

Synonyms:CBX4; hPc2; NBP16; PC2;

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

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