Immunological Sciences

CD146 Rabbit Monoclonal Antibody

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Catalog Number:MABN87470
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:A synthetic peptide of human CD146
Reactivity:Human
Applications:WB 1:1000-1:5000
Molecular Weight:Calculated MW:72 kDa; Observed MW:120 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:CD146; MUC18

Applications

WB 1:1000-1:5000

Immunogen

A synthetic peptide of human CD146

Target Background

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Synonyms:CD146; MUC18

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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