Immunological Sciences

CD163 Rabbit Monoclonal Antibody

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Catalog Number:MABN86751
Conjugate:Unconjugated
Size:100μL
Concentration:1mg/ml
Host:Rabbit
Isotype:IgG
Clone:Monoclonal
Immunogen:Recombinant protein of mouse CD163
Reactivity:Human,Mouse,Rat
Applications:WB 1:500-1:2000,IHC 1:200-1:500,FC 1:50-1:100
Molecular Weight:Calculated MW:126 kDa; Observed MW:150 kDa
Purification:Affinity Purification
Form:Liquid
Synonyms:CD163v2; CD163v3

Applications

WB 1:500-1:2000,IHC 1:200-1:500,FC 1:50-1:100

Immunogen

Recombinant protein of mouse CD163

Target Background

Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity).

Synonyms:CD163v2; CD163v3

Storage

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

Buffer

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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